刘磊-江苏大学材料科学与工程学院

　姓名：刘磊　 (博士生导师)

　职称：研究员

　地址：江苏大学新材料研究院

　Telephone：18206102793

　Fax：

　E-mail：liul@ujs.edu.cn

　研究方向：

扫描探针显微技术在生物学中应用，
生物表面界面分析
生物分子自组装与疾病致病机理研究，
生物抗菌材料的研究
（欢迎具有化学，材料学，生物化学，生物学背景的研究生报考，有意向者可发邮件联系：liul@ujs.edu.cn）

　教育经历：

2000-2004 哈尔滨理工大学化学环境与工程学院学士
2005-2010 国家纳米科学中心物理化学博士
2010-2013 丹麦奥胡斯大学多学科交叉纳米中心（iNANO Center）博士后
2014-至今江苏大学新材料研究院江苏特聘教授，研究员，青年特聘教授
2016-至今江苏省创新创业人才计划（高校创新类）

　教学经历：

　项　　目：

1、国家自然科学基金面上项目(21573097)，淀粉样多肽自组装结构调控对其力学性质以及生物学性质的影响， 2016.01-2019.12， 78.6万主持，在研
2、国家自然科学基金青年科学基金项目（51503087），潜在抗菌材料淀粉样多肽纳米聚集体与细菌膜的相互作用研究，2016.01-2018.12，25.8万, 主持，在研
3、江苏特聘教授, 2014年，材料科学，2014-2017, 100万，主持，在研
4、江苏省创新创业人才计划，2016年，2017-2019, 50万，主持，在研
5、江苏省自然科学基金青年基金（BK20140528），淀粉样多肽及其纳米聚集体作为潜在抗菌剂与细菌膜项目作用以及抗菌机理研究，2014.7-2017.6, 20万，主持，在研
6、江苏大学科研启动基金、14JDG021、多肽自组装纳米结构的构筑与调控、2014-2017、10 万元、主持；在研
7、丹麦国家基金委项目、430007、核酸纳米技术项目子课题、2009-2017、4450 万丹麦克朗、参与，在研；
8、中丹合作子项目、26-332-5-434011、表面纳米结构的自组装和功能、2009-2015、150 0万丹麦克朗、参与，结题；
9、丹麦政府支持独立科技研究项目、10-082800(436979)、利用扫描探针显微技术进行蛋白质识别，单个细胞的可视化研究、2010-2013、309.8 万丹麦克朗、参与，结题

　奖　　项：

2010 中科院宝洁奖

　学术组织和学术活动：

学术兼职：
1）候选人目前担任Journal of Nanomaterials的客座编辑，
2）Nature Publishing Group (NPG)，Scientific Reports，美国化学会旗下ACS Nano，英国皇家化学会旗下Nanoscale等多个期刊审稿人，
3）担任2015-3M-NANO国际纳米会议和2016-SIS表面活性剂国际会议的学术分会主席，
4）3M-NANO国际会议（2017-IEEE international conference on manipulation，manufacturing and measurement on the nanoscale）常务委员会委员。

　论文专著专利：

5篇代表性论文：
1、 Lei Liu, Lin Niu, Meng Xu, Qiusen Han, Hongyang Duan, Mingdong Dong, Flemming Besenbacher, Chen Wang,* and Yanlian Yang*. Molecular tethering effect of C-terminus of amyloid peptide Aβ42. ACS Nano. 2014, 8, 9503-9510. （一区）
2、 Lei Liu, Lang Zhang, Lin Niu，Meng Xu, XiaoBo Mao, Yanlian Yang* and Chen Wang*. Observation of Reduced Cytotoxicity of Aggregated Amyloidogenic Peptides with Chaperone-like Molecules. ACS Nano. 2011, 5, 6001-6007. （一区）
3、 Lin Niu, Lei Liu (共同一作), Meng Xu, Jacob Cramer,Kurt V. Gotherlf, Mingdong Dong, Flemming Besenbacher, Qingdao Zeng, Yanlian Yang, Chen Wang*. Transformation of beta sheet structure of amyloid peptide induced by molecular modulators. Chem. Commun. 2014, 50, 8923-8926.（一区）
4、 Lin Niu, Lei Liu (共同一作), Wenhui Xi, Qiusen Han, Qiang Li, Yue Yu, Qunxing Huang, Fuyang Qu, Meng Xu, Yibao Li, Huiwen Du, Rong Yang, Jacob Cramer, Kurt V. Gothelf, Mingdong Dong, Flemming Besenbacher, Qingdao Zeng, Chen Wang*, Guanghong Wei*, Yanlian Yang*. Synergistic inhibitory effect of Peptide-Organic Co-assemblies on Amyloid Aggregation. ACS Nano, 2016, 10, 4143−4153. （一区）
5、 Jakob Knudsen, Lei Liu，et al, Routing of individual polymers in designed patterns. Nature Nanotech. 2015, 10, 892-899. (一区，IF=34, 封面文章)

全部论文：
第一作者或通讯作者，20篇
1. Guodong Yang, Lei Liu*, Jie Wang, Christian Bortolini, Mingdong Dong*. Light-driven porphyrin modulating fibrillation of hIAPP20-19 peptide. Journal of Colloid and Interface Science. 2017, 495, 37-43. (二区，通讯作者)
2. Lei Liu, Qiang Li, Shuai Zhang, Xiaofeng Wang, Søren Vrønning Hoffmann, Jingyuan Li, Zheng Liu, Flemming Besenbacher*, Mingdong Dong*, Identification of a novel parallel β-stand conformation within molecular monolayer of amyloid peptide, Advanced Science, 2016, 1500369, 1-10. (一区，封面类文章)
3. Lin Niu, Lei Liu (共同一作), Wenhui Xi, Qiusen Han, Qiang Li, Yue Yu, Qunxing Huang, Fuyang Qu, Meng Xu, Yibao Li, Huiwen Du, Rong Yang, Jacob Cramer, Kurt V. Gothelf, Mingdong Dong, Flemming Besenbacher, Qingdao Zeng, Chen Wang*, Guanghong Wei*, Yanlian Yang*. Synergistic inhibitory effect of Peptide-Organic Co-assemblies on Amyloid Aggregation. ACS Nano, 2016, 10, 4143−4153. （一区）
4. J Wang, Z Zhu, C Bortolini, S V Hoffmann, A Amari, H X Zhang, Lei Liu*, Mingdong Dong*. Dimensionality of carbon nanomaterial impacting on the modulation of amyloid peptide assembly. Nanotechnology. 2016, 27, 304001(1-7). (二区)，通讯作者）
5. Liguo Tao, Yunpeng Cao, Cuixia Ma, JieWang, Lin Lin, Lei Liu*, and Mingdong Dong. Probing the amyloid peptide-membrane interaction using a liposome model system. Journal of Self-Assembly and Molecular Electronics, 2016, 1, 1–18. (通讯作者)
6. Lei Liu, Yibao Li, Dan Xia, Christian Bortolini, Shuai Zhang, Yanlian Yang, Jan. S.Pedersen, Chen Wang, Flemming Besenbacher, Mingdong Dong*. Self-assembled nanopatch with peptide-organic multilayers and mechanical property. Nanoscale. 2015, 7, 2250-2254. （一区）
7. Ruirui Xing, Tifeng Jiao,* Linyin Yan, Guanghui Ma, Lei Liu,* Luru Dai, Junbai Li, Helmuth Möhwald, and Xuehai Yan* Colloidal Gold−Collagen Protein Core−Shell Nanoconjugate: One-Step Biomimetic Synthesis, Layer-by-Layer Assembled Film, and Controlled Cell Growth. ACS Appl. Mater. Interfaces 2015, 7, 24733−24740 (一区，通讯作者)
8. Lin Lin, Haiying Cui, Hui Zhou, Xuejing Zhang, Christian Bortolini, Menglin Chen, Lei Liu* and Mingdong Dong*. Nanoliposomes containing Eucalyptus citriodora as antibiotic with specific antimicrobial activity. Chem. Commun. 2015, 51, 2653-2655. (一区，通讯作者)
9. Wang, J.; Cao, Y. P.; Li, Q.; Liu, L.*; Dong, M. D.*, Size Effect of Graphene Oxide on Modulating Amyloid Peptide Assembly. Chemistry-A European Journal, 2015, 21, 9632-9637. (二区，通讯作者)
10. Lei Liu, Lin Niu, Meng Xu, Qiusen Han, Hongyang Duan, Mingdong Dong, Flemming Besenbacher, Chen Wang,* and Yanlian Yang*. Molecular tethering effect of C-terminus of amyloid peptide Aβ42. ACS Nano. 2014, 8, 9503-9510. （一区）
11. Lin Niu, Lei Liu (共同一作), Meng Xu, Jacob Cramer,Kurt V. Gotherlf, Mingdong Dong, Flemming Besenbacher, Qingdao Zeng, Yanlian Yang, Chen Wang*. Transformation of beta sheet structure of amyloid peptide induced by molecular modulators. Chem. Commun. 2014, 50, 8923-8926.（一区）
12. Qiang Li, Lei Liu(共同一作), Shuai Zhang, Meng Xu, Xueqing Wang, Chen Wang, Flemming Besenbacher, Mingdong Dong*. Modulating Aβ33-42 peptide assembly by graphene oxide. Chem. Eur. J. 2014, 20, 7236-7240.（二区）
13. Guanghong Zeng, Lei Liu (共同一作), Dan Xia, Qiang Li, Zhuo Xin, JianGuo Wang, Flemming Besenbacher, Troels Skrydstrup and Mingdong Dong*. Transition of Chemically modified diphenylalanine peptide assemblies revealed by atomic force microscopy. RSC Adv. 2014, 4, 7516-7520. （二区）
14. Lei Liu, Dan Xia, Lasse H. Klausen, Mingdong Dong* The Self-Assembled Behavior of DNA Bases on the Interface. Int. J. Mol. Sci. 2014, 15, 1901-1914. （三区）
15. Lei Liu, Lang Zhang, Lin Niu，Meng Xu, XiaoBo Mao, Yanlian Yang* and Chen Wang*. Observation of Reduced Cytotoxicity of Aggregated Amyloidogenic Peptides with Chaperone-like Molecules. ACS Nano. 2011, 5, 6001-6007. （一区）
16. Lei Liu, Katerina Busuttil, Shuai Zhang, Yanliang Yang, Chen Wang, Flemming Besenbacher and Mingdong Dong*. The role of self-assembling polypeptide in building nanomaterials. Phys. Chem. Chem. Phys. 2011, 13, 17435-17444. (二区，封面类文章)
17. YinLi Li，Lei Liu,(共同一作), Ramesh Subramani, Yunxiang Pan, Bo Liu, Yanlian Yang, Chen Wang, Wael Mamdouh, Flemming Besenbacher and Mingdong Dong*. Building layer-by-layer 3D supramolecular nanostructures at the terephthalic acid/stearic acid interface. Chem. Commun. 2011, 47, 9155-9157.（一区）
18. Lei Liu, Yanlian Yang, Chen Wang*, Yang Yao, Seng Hou, Xizeng Feng*. Polymeric effects on DNA condensation by cationic polymers observed by atomic force microscopy. Colloids and Surface B: Biointerface. 2010, 75, 230-238. （二区）
19. Lei Liu, Lan Zhang, Xiaobo Mao, Lin Niu, Yanlian Yang*, Chen Wang*. Chaperon-mediated single molecular approach towards modulating Aβ peptide aggregation. Nano Lett. 2009, 9, 4066-4072. （一区）
20. Xiaojing Ma, Lei Liu. (共同一作), Xiaobo Mao, Lin Niu, Ke Deng, WeihuiWu, YanMei Li, Yanlian Yang, Chen Wang*. Amyloid-β (1-42) folding multiplicity and single molecule binding behavior studied by STM. J. Mol. Biol. 2009, 388, 894-901. （二区）

其它共同作者论文：22篇
21. Jakob Knudsen, Lei Liu，et al, Routing of individual polymers in designed patterns. Nature Nanotech. 2015, 10, 892-899. (一区，IF=34, 封面文章)
22. De-Zhen Sun, Yang-Yang Yu, Rong-Rong Xie, Chun-Lian Zhang, Yuan Yang, Dan-Dan Zhai, Guodong Yang, Lei Liu, Yang-Chun Yong*. 2017. In-situ growth of graphene/polyaniline for synergistic improvement of extracellular electron transfer in bioelectrochemical systems. Biosensors & Bioelectronics, 87, 195-202. (一区, IF=7.4)
23. Zhang, P.; Hou, X. L.; Lei, Liu.; Mi, J. L.; Dong, M. D.*, Two-Dimensional π-Conjugated Metal Bis(dithiolene) Complex Nanosheets as Selective Catalysts for Oxygen Reduction Reaction. J. Phys. Chem. C 2015, 119, 28028-28037. （二区）
24. Zhang, P.; Hou, X. L.; Mi, J. L.; Lei, Liu; Dong, M. D.* Oxygen reduction reaction on M-S4 embedded graphene: A density functional theory study. Chem. Phys. Lett. 2015, 641, 112-116. （三区）
25. Wang, X. F.; Weber, J. K.; Lei Liu.; Dong, M. D.; Zhou, R. H.; Li, J. Y.A novel form of β-strand assembly observed in Aβ33–42 adsorbed onto graphene. Nanoscale, 2015, 7, 15341-15348. （一区）
26. Yunpeng Cao, Liguo Tao, Jie Wang, Hüsnü Aslan, Lei Liu, Mingdong Dong*, AFM Study on Amyloid Peptide – Graphene Oxide Assembly and Its Interaction with Liposome. JSAME. 2015, 3, 1-16.
27. Christian Bortolini, Lei Liu, Thomas M.A. Gronewold, Chen Wang, Flemming Besenbacher and Mingdong Dong*. The position of hydrophobic residues tunes peptide self-assembly. Soft Matt. 2014, 10, 5656-5661. （二区）
28. Christian Bortolini, Lei Liu, Zhenshen Li, Karen Thomsen, Chen Wang, Flemming Besenbacher* and Mingdong Dong*. Identification of cysteine-rich peptide fiber by specific cysteine-Au nanoparticles binding on fiber surface. Adv. Mater. Interfaces. 2014, DOI: 10.1002/admi.201400133. （三区）
29. Lin Lin, Haiying Cui, Ronghai He, Lei Liu, Cunshan Zhou, Wael Mamdouh, Haile Ma, Effect of ultrasonic treatment on the morphology of casein particles., Ultrasonics Sonochemistry 2014, 21, 513–519. （二区）
30. Shuai Zhang, Maria Andreasen, Jakob T. Nielsen, Lei Liu, Erik H. Nielsen, Daniel E. Otzen, Mingdong, Dong*. Coexistence of ribbon and helical fibrils originating from hIAPP20-29 revealed by quantitative nanomechanical atomic force microscopy. Proc. Natl. Acad. Sci., USA, 2013, 110, 2798-803. (一区，highlight by nature chemistry)
31. Xiaobo Mao, Yuanyuan Guo, Yin Luo, Lin Niu, Lei Liu, Xiaojing Ma, Huibin Wang, Yanlian, Yang, Guanghong Wei and Chen Wang*. Sequence effects on peptide assembly characteristics observed by using scanning tunneling microscopy. J. Am. Chem. Soc. 2013, 135, 2181-2187. （一区）
32. Jie Song, Zhao,Zhang, Shuai Zhang, Lei Liu, Qiang Li, Erqing, Xie, Kurt. V. Gothelf, Flemming Besenbacher, Mingdong Dong*. Isothermal hybridization kinetics of DNA assembly of two dimensional DNA origami. Small. 2013, 9, 2954-2959. （一区）
33. Song, S.; Cheong, L. Z.; Falkeborg, M.; Lei, Liu.; Dong, M.; Jensen, H. M.; Bertelsen, K.; Thorsen, M.; Tan, T.; Xu, X.; Guo, Z. Facile synthesis of phosphatidyl saccharides for preparation of anionic nanoliposomes with enhanced stability. Plos ONE, 2013, 8, e73891.（二区）
34. Jie Song, Jean-Michel Arbona, Zhao Zhang, Lei Liu, Erqing Xie, Juan Elezgaray, Jean-Pierre Aimé, Kurt V. Gothelf, Flemming Besenbacher, and Mingdong Dong*. Direct Visualization of Transient Thermal Response of a DNA Origami. J. Am. Chem. Soc. 2012, 134, 9844-9847. （一区）
35. Xiao-Bo Mao, Chen-Xuan Wang, Xing-Kui Wu, Xiao-Jing Ma, Lei Liu, Lan Zhang, Lin Niu, Yuan-Yuan Guo, Deng-Hua Li, Yan-Lian Yang, and Chen Wang*. Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies. Proc. Natl. Acad. Sci., USA, 2011, 108, 19605-19610. （一区）
36. Xiaobo Mao, Yuanyuan Guo, Chenxuan Wang, Min Zhang, Xiaojing Ma, Lei Liu, Lin Niu, Qingdao Zeng, Yanlian Yang, and Chen Wang*. Binding Modes of Thioflavin T Molecules to Prion Peptide Assemblies Identified by Using Scanning Tunneling Microscopy. ACS Chem. Neurosci. 2011, 2, 281-287. （二区）
37. Xiaobo Mao, Chenxuan Wang, Xiaojing Ma, Min Zhang, Lei Liu, Lan Zhang, Lin Niu, Qindao Zeng, Yanlian Yang and Chen Wang*. Molecular level studies on binding modes of labeling molecules with polyalanine peptides. Nanoscale. 2011, 3, 1592-1599. （一区）
38. Yang Yao, Dao-Fu Feng, Yi-Pan Wu, Qi-Jun Ye, Lei Liu, Xin-Xin Li, Sen Hou, Yan-Lian Yang, Chen Wang, Lei Li, and Xi-Zeng Feng*. Influence of block sequences in polymer vectors for gene transfection in vitro and toxicity assessment of zebrafish embryos in vivo. J. Mater. Chem. 2011, 21, 4538-4545.（一区）
39. Xiaobo Mao, Chenxuan Wang, Lei Liu, Xiaojing Ma, Lin Niu, Yanlian Yang,Chen Wang*. Study on the Fine Structure of polypeptides at Solid-liquid Interfaces by Scanning Tunneling Microscopy. Acta Physico-Chimica Sinica. 2010, 26, 850-861.（四区）
40. Lin Niu, Xiaojing Ma, Lei Liu, Xiaobo Mao, Dongxia Wu, Yanlian Yang, Qingdao Zeng,* Chen Wang*. Molecularly tuned peptide assemblies at liquid/solid interface studied by scanning tunneling microscopy. Phys. Chem. Chem. Phys. 2010, 12, 11683-11687.（二区）
41. X.B Mao, X.J. Ma, Lei Liu, Niu, L., Yang, Y. L., and Wang, C*. Structural characteristics of the beta-sheet-like human and rat islet amyloid polypeptides as determined by scanning tunneling microscopy. J. Struct. Biol. 2009, 167, 209-215. （三区）
42. Mao, X. B., Wang, Y. B., Lei Liu, Niu, L., Yang, Y. L., and Wang, C*. Molecular-Level Evidence of the Surface-Induced Transformation of Peptide Structures Revealed by Scanning Tunneling Microscopy. Langmuir. 2009, 25, 8849-8853. （二区）

编写专著：
Self-assembly of DNA bases via hydrogen bonding studied by Scanning tunneling microscopy. L Liu, F. Besenbacher and M. Dong
Kjems/Ferapontova/Gothelf (Eds.): Nucleic Acids Nanotechnology
Series “Nucleic Acids and Molecular Biology” (Series Editor: J. Bujnicki) 施普林格出版社，2014年, DOI 10.1007/978-3-642-38815-6

专利：
1. 刘磊，杨延莲，王琛. 氮杂环化合物在制备抑制淀粉样多肽毒性的药物中的应用. 2010. 中国. ZL201010299602.3
2. 刘磊，董明东. 有机小分子调控多肽组装形成二维多肽纳米薄片的方法. 2012. 中国，ZL201210234629.3
3. 曾光洪，刘磊，董明东. 一种通过溶剂处理制备多肽纳米薄膜的方法. 2012. 中国， ZL201210233011.5